Clinical Trials in Orthopedic Surgery
نویسنده
چکیده
A clinical trial may be defined as a ‘‘planned experiment’’ that involves patients, and it is designed to elucidate the most appropriate treatment of future patients with a given medical condition. The first step in designing a clinical trial is to select the best study type. The major types are the case report, the case series, case control studies, cohort study, and the most rigorous of all study designs; the randomized controlled trial (RCT). The basic design features of an RCT are randomization including stratification, permuted blocks, timing and blinding, measurement of outcome, sample size, analysis, and feasibility.
منابع مشابه
Effect of Topical Vancomycin on Prevention of Surgical Site Infection in Spinal Surgery
Background and purpose: Surgical site infection (SSI) is one of the most commonly reported post-operative condition. The purpose of this study was to evaluate the effect of topical vancomycin powder on prevention of SSI in spinal surgery. Materials and methods: A single blind clinical trial was performed in 200 patients who were randomly divided into two groups. In both groups IV injection of ...
متن کاملComparing the Effect of Alendronate and Vitamin D Administration on Lumbosacral Fusion and Severity of Low Back Pain in Patients After Posterior Lumbar Fusion Surgery: A Randomized Clinical Trial
Background and purpose: Bone fusion is a dynamic process and availability of calcium and balance of vitamin D can be effective in post spinal cord fusion. There are contradictory results on this issue, so, we decided to compare the effect of administration of vitamin D and alendronate on lumbosacral vertebral fusion in patients undergoing posterior spinal fusion surgery. Materials and methods:...
متن کاملIntravenous Paracetamol Reduces Postoperative Opioid Consumption after Orthopedic Surgery: A Systematic Review of Clinical Trials
Postoperative pain management is one of the most challenging jobs in orthopedic surgical population as it comprises of patients from extremes of ages and with multiple comorbidities. Though effective, opioids may contribute to serious adverse effects particularly in old age patients. Intravenous paracetamol is widely used in the postoperative period with the hope that it may reduce opioid consu...
متن کاملOrthopedic Trauma Surgeries in COVID-19 Pandemic; A Trauma Management Algorithm
After the COVID-19 outbreak worldwide, we will sooner or later encounter trauma patients with COVID-19 in thedeveloping countries. It is a challenging decision-making process for an orthopedic surgeon to provide the patients withthe best practice in the crisis. Here we discuss the issue in terms of clinical severity of COVID-19 pneumonia, priorityof orthopedic surgical trauma ...
متن کاملComparison of Custom-made Versus Prefabricated Thumb Splinting for Carpometacarpal Arthrosis: A Systematic Review and Meta-analysis
Background: The goal of this study was to compare the two types of orthoses, prefabricated soft splints versus shortthermoplastic custom-made splints, that are the most commonly used for the management of first carpometacarpal(CMC) osteoarthritis (OA).Methods: We conducted a meta-analysis and systematic review in the literature based on the Preferred ReportingItems for Systematic Reviews and Me...
متن کاملComparison of Clinical Results between Patellar Resurfacing and Non-resurfacing in Total Knee Arthroplasty: A Short Term Evaluation
Background: There is no difference in the functional outcomes 6 months after total knee arthroplasty (TKA) for kneeosteoarthritis between patellar resurfacing and non-resurfacing. Thus, we have performed this study to compare theshort-term clinical outcomes of TKA performed with and without the patella resurfacing.Methods: A total of 50 patients with osteoarthritis of the knee (OAK) were random...
متن کامل